Then we need to explain why this suddenly became a problem in the 1970s. Life is more boring now? We all lost our willpower? People understood nutrition better before that? Something has changed, either in humanity or the environment. My bet is the environment.
Since theres no blood brain barrier here, these neurons get damaged easily due to things in the blood. When that happens, they don't see leptin anymore, and obesity develops. Fructose and high fat diets have both been shown to cause inflammation here. (hypothalamic gliosis)
heres a random selection of many papers http://diabetes.diabetesjournals.org/content/65/3/551.figure...
We also know that certain viruses show up in obese people (adenovirus36). As the field develops, I would not be surprised if labs demonstrate both viral infection of the hypothalamic ARC and damage by endocrine disruptors there.
What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition?
> if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure.
Sounds like nonsense, can you elaborate?