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Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by Aloha on Thursday April 12, 2018 @06:22AM (#16819420)
In every US state that I know of - a generic will be substituted for a brand name drug unless the doctor specifically specifies that it should not be.
Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by alistairSH on Thursday April 12, 2018 @10:37AM (#16821356)
There's a subtle difference between what you're describing and what the parent post describes.

You are correct - in cases where there is a brand-name version of a dug AND also a generic version of the same drug, the generic is usually provided unless the brand-name is specifically requested.

But, the parent post is describing cases where there is a new, brand-name drug that fills the same niche as an existing generic. Two different drugs, but often only slightly differing results. MDs often prescribe the newest, assuming it's better than the generic. MDs receive much of their ongoing education about drugs from the pharmaceutical sales reps, so they are bombarded with ads and samples (just as consumers are with ads on TV).

As an aside, my dermatologist has been good about ensuring the costs of any treatments I receive are managed. She's recommended specific pharmacies, brand-name vs generic, and other tips/tricks to reduce the costs. This despite the fact that I don't directly bear any of the costs because I have a decent medical plan.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by ubernostrum on Thursday April 12, 2018 @12:58PM (#16822800)
MDs often prescribe the newest

That is not always a correct assumption. Due to the way some programs like Medicare pay out, doctors are sometimes strongly incentivized to prescribe the most expensive drug.

Ophthalmologists are the usual notorious example, prescribing for macular degeneration. Medicare's reimbursement for drugs administered in-office includes paying the cost of the drug plus an additional percentage.

For macular degeneration, research showed Avastin and Lucentis are basically equally effective. But Avastin is ~$50/dose and Lucentis is ~$2,000/dose. If you're going to get a "bonus" payment equal to a percentage of the cost of the drug, which one would you use?

Lucentis has at times accounted for 10% of the entire Medicare part B drug budget because of this.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by alistairSH on Thursday April 12, 2018 @03:06PM (#16823945)
Wow! I didn't know about that quirk of the Medicare system. That's a pretty horrific incentive to overspend.

My comment was based on the more typical situation, where the physician sends the patient to a pharmacist.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by LordKano on Thursday April 12, 2018 @12:20PM (#16822425)
It sounds like your dermatologist is not just a good doctor but also a good person.

Giving the same (high?) standard of care to patients without regard to their financial resources.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by avar on Thursday April 12, 2018 @06:45AM (#16819518)
I was unclear, the podcast discusses cases where there's no generic version of the latest drug, and the latest drug is marginally more effective than whatever the latest generic is.

So the generic just doesn't get considered, even though it would be suitable for the patient at much lower costs. This is unrelated to the situation you're describing.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by Aloha on Thursday April 12, 2018 @08:51AM (#16820320)
Having a medical condition that requires long term medication maintenance - every single doctor I've had is very well aware of what is a generic and what is not - and tends to prescribe a generic, as they are often an ER version of the regular med, or a compounded version of two medications that can be taken separately.
Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by cko on Thursday April 12, 2018 @09:31AM (#16820700)
Former pharmacist here. I think most doctors do try to be cost conscious for the patient. But there are some who prescribe the newest and expensive brand name drug, and I can’t think of any reason why except some sort of incentive program.

Many ophthalmologists will give the most expensive post surgical drops. When I called one to have him change it, he was like “uh, there’s no substitute.” I thought to myself, “then what did you guys do before these drugs came out a couple months ago?” Example: post cataract surgery people usually get an antibiotic, a corticosteroid, and an anti inflammatory. These generic drugs have been on the market for years. But new ones come out here and there that are hella expensive, we’re talking a copay of $5.00 vs $100+ per eye drop.

Also there are prescribing guidelines called step therapy. For example for diabetes: https://emedicine.medscape.com/article/117853-treatment#d10 doctors will skip the first few steps and prescribe a brand name drug immediately that’s like step 3.

Insurance companies try to stop it by requiring authorization but... I feel like we’re fighting an uphill battle with perverse incentives.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by refurb on Thursday April 12, 2018 @10:01AM (#16820975)
In my former job, I talked to a lot of doctors about this stuff.

What I found was that a lot of doctors look at the decision from a clinical lens only. Why not prescribe the latest branded product, even if it's only marginally better than the generic? Patients deserve the best, right?

Making a cost vs. benefit trade off wasn't a universal process for many physicians.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by darpa_escapee on Thursday April 12, 2018 @11:51AM (#16822173)
I've actually run into a very similar example, I was prescribed a $400 dollar bottle of antibiotic eye drops, which my insurance fought and eventually paid for. I asked why that was chosen and if there were other options that I could pursue in the future. I was told that "these are your eyes and I'm not going to [fuck around] when it comes to your vision."

I can't really disagree with that logic.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by cko on Thursday April 12, 2018 @06:25PM (#16825502)
True, but what did doctors do before these new drugs? “Fuck around” with “inferior” products... reason I’m cynical is because many new drugs that hit the market are not novel - for example loteprednol (older drug) vs difluprednate (newer): https://www.ncbi.nlm.nih.gov/m/pubmed/28628490/

By the way, some of these newer drugs don’t have to be “superior” to be approved, they just have to be none-inferior to current therapy. https://www.raps.org/regulatory-focus™/news-articles/2016/11...

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by darpa_escapee on Thursday April 12, 2018 @06:29PM (#16825526)
From what I gathered, it was more effective than the cheaper options, not that it was chosen because it was new and shiny.
Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by kbart on Thursday April 12, 2018 @03:34PM (#16824176)
"a generic will be substituted for a brand name drug"

We had a similar corruption here, in Lithuania, until the law has been passed that pharmacist must offer a generic alternative. But there again, world is seen very differently in EU than USA, so I don't expect that to apply on the other side of the pond.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by cptskippy on Thursday April 12, 2018 @09:38AM (#16820755)
And drug makers are aware of this fact thus they incentivize doctors to specify the brand name drug.
Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by thesimon on Thursday April 12, 2018 @11:55AM (#16822200)
And this makes the pharmacy give you the brand name drug?

That's surprising. Over here (Germany) the doctor can fill in the name of the brand in the prescription, but unless he ticks a special box you'll automatically get the generic.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by pbhjpbhj on Thursday April 12, 2018 @07:29PM (#16825851)
Why would a pharmacy give you a brand name, the generic is chemically identical, the doctor can give a brand name - they've done their part. The pharmacy could then offer you the brand name, or the generic, as long as they make the generic cheaper then the pharmacy can make more money; save you money and give identical service.

Some people will still opt for the more expensive, of course, but where's the incentive for the pharmacist to fill a script for Neurofen RTM with anything other than ibuprofen? Why even is there a special box -- if the generic isn't the same drug (tested, licensed, etc.) it's not a generic. Might as well have a "are you getting a kickback for prescribing this" box?

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by stordoff on Friday April 13, 2018 @06:42AM (#16828678)
Generics aren't always chemically identical. The active ingredient might be the same, but the binders may not be. In the majority of cases, that's fine - you only really care about the active ingredient - but in certain cases, such as a sensitivity to one of those ingredients, it might not be. My sister has had to have specific brands of certain medicines prescribed due to a sensitivity to certain types of sugars. For instance, compare Neurofen:

> Each tablet contains Ibuprofen 200 mg Also contains: Sucrose, Sodium Citrate, talk, Croscarmellose Sodium, Stearis Acid, Titaniu, Dioxide, Silicon Dioxide, Acacia, Carmellose Sodium, Sodiu, Laurilsulphate, Macrogol and Blank Ink(contains Shellac, Iron Oxide Black (E172) and Propylene Glycol) or Opacode S -1 -8152 HV Black (contains Shellac, Iron Oxide Black (E172, Antifoam DC1510 and Soya Lecithin

https://www.boots.com/nurofen-200mg-tablets-16-tablets

to generic ibuprofen:

> Ibuprofen 400mg, sodium starch glycollate, croscarmellose sodium, sucrose, E171, E127 and E211

https://www.chemistdirect.co.uk/ibuprofen-400mg-tablets/prd-...

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by chimeracoder on Thursday April 12, 2018 @10:06AM (#16821030)
> And drug makers are aware of this fact thus they incentivize doctors to specify the brand name drug.

That's a bold and unfounded claim. Drug makers do not incentivize doctors to write DAW on a prescription.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by cptskippy on Thursday April 12, 2018 @10:29AM (#16821263)
> That's a bold and unfounded claim.

Forbes and the New York Times have written articles on it. The Affordable Care Act has a provision that requires Doctors to disclose payments.

Empirically, I dated a girl for about 2 years who was a sales representative for a major pharmaceutical company. When I asked about her job she said it was mostly dropping of brochures, swag, free lunches, and holding contests to promote products. Top producers (doctors) received all expense paid trips to medical conferences held in exotic locations or were invited to be paid speakers at said conferences. It was not too different from what the marketers did at the insurance broker I worked for at the time to cater Agents to write their lines.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by chimeracoder on Thursday April 12, 2018 @10:36AM (#16821346)
> Empirically, I dated a girl for about 2 years who was a sales representative for a major pharmaceutical company. When I asked about her job she said it was mostly dropping of brochures, swag, free lunches, and holding contests to promote products. Top producers (doctors) received all expense paid trips to medical conferences held in exotic locations or were invited to be paid speakers at said conferences. It was not too different from what the marketers did at the insurance broker I worked for at the time to cater Agents to write their lines.

Your anecdote is about which drugs the doctors choose to prescribe. It has nothing to do with incentivizing doctors to prevent patients from filling generic versions of drugs and forcing them to purchase the brand-name version of the same drug, which is what this thread is about.

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by cptskippy on Thursday April 12, 2018 @10:47AM (#16821458)
They weren't compensating them to fill scripts for the generic. She made more frequent visits to top producers based on filled prescriptions. I asked her how she knew who to visit and she said she was emailed regional reports with prescription numbers.

I don't know how those reports are generated. Do pharmacies report that information back to pharmaceutical companies? Are they based off of shipments to regions?

Re:Non-profit’s $300 hepatitis C cure as effective as $84k a... by chimeracoder on Thursday April 12, 2018 @11:33AM (#16821996)
> They weren't compensating them to fill scripts for the generic.

They're not out there to make sales for old drugs (drugs that have gone generic). They're out there to make sales for new drugs, which don't have generic equivalents at all.

No pharmaceutical company is going to waste money on sales for drugs that have gone generic, and certainly no pharmaceutical company is going to try and incentivize providers to DAW prescriptions. Aside from being already illegal, even an unscrupulous company wouldn't bother because it'd be a tremendous waste of money.