Quines also live in an environment: the programming language they're written in. It's a very different _kind_ of environment; for instance the physical world has preservation of mass while it's really easy to copy bits. But both quines and proto-life can only replicate in the right environment, and they do so via an interaction between the information contained in themselves and the environment in which they are embedded. They seem quite analogous to me.
That's the problem with analogies: they are observer-dependent.
A quine shares no causal property with DNA.
"assembling a copy of yourself" is a description you are imposing on a series of events.
The events in the case of a digital computer are certain oscillations to the electric field. That shares nothing with the chemical assembly of biological material
"Neurons" arent neurons. Replication isnt replication.
AI proponents speak of photographs of animals made of ink (electrical fields in silicon) as-if they were themselves animals. Inviting us to marvel at how life-like the piece of paper is.
I never understood why people assume that those biological self-replicators were in any way analogous to quines. Quines generate information from within themselves. Proto-life would have to assemble copies of itself from molecules available in the environment. It seems like completely different principles of work.