The newer version of signature spoofing patch (included in microG's LineageOS fork) allows you to control the spoofing and make sure that it's only used when necessary and permitted, so I'd say the answer is "no".

Interesting. I know the microG folks tried to upstream a patch to Cyanogenmod, which the devs shot down almost immediately.. So you're saying that the microG folks are now maintaining a fork of LineageOS? If it's not tracking VERY closely to upstream LineageOS, then it's probably not worth it.

https://lineage.microg.org/ - tracking very closely, just adding the spoofing patch and preinstalling microG, F-Droid etc.

IIRC all the spoofing patches required a special app permission to spoof.

IIRC the newer version requires the app to not only have the permission, but also be installed as a system app, so you can't install it accidentally.