I fast every other day (the EODF method the paper studied). It's actually surprisingly easy and from what I can tell from the (no more than a dozen) sources I've read it's just as effective as longer-term fasts. I've been at it since July, with two weekly breaks basically. I was also overweight before starting. My BMI went from 26.3 to 24.2 since then, something I had been trying to achieve for at least a couple of years, with no success.
I'd also be interested to hear from someone with a medical or biological background. I'm particularly interested in the effects of fasting on blood pressure and kidneys. I have an older relative who is a kidney patient and overweight which probably contributes to their high blood pressure and it'd be great if I could recommend they follow my diet.
Can you explain your process more? Do you hold not eat for 18 or so hours for those 6 days?
I've been testing fish oil to convince the gallbladder to empty because developing gallstones doesn't sound fun.
Background: I'm currently about 35 lbs. / 16 kg. overweight, which was partially medication-contributed but I also picked up the proverbial fork, and now I'm just not very hungry.
Related but different, perhaps someone with a bio/med background knows: Regarding the metformin FDA Phase 4 clinical trial for life extension and a conflicting recommendation from my PCP that metformin (1500 mg) has a significant risk of injury from acute hypoglycemia in those (like yours truly) without type-2 diabetes but being overweight (about 20%). I didn't see anything in the literature or box warnings about common hypoglycemia risks, especially in good liver & kidney functional patients, and the body can regulate glucose with a panoply of pathways. Seems to me, metformin looks like it has massive potential to benefit many people to up-regulate healthy pathways, but only if doctors understood its limitations and capabilities in settings outside of diabetes. Or am I missing or wrong about something?
https://clinicaltrials.gov/ct2/show/NCT02432287
https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral...
https://www.drugs.com/sfx/metformin-side-effects.html