Do they react to what the player is looking at or where they're standing? I think what the GP meant was that "you can't have David Attenborough going on about the lovely penguins whilst the user is staring at some polar bears."
The form of presentation impacts blocking and scene-changes. Theater in the round would result in different staging than a traditional auditorium, for example.
A 360 degree movie is essentially the inverse of the theater experience. Instead of fixed locations pointing towards the action, the viewer is in the center of the world with potential for action all around.
People will pay attention to what's happening, there's no need to worry too much about someone simply ignoring the action. Besides, even casual YouTubers do positional sound nowadays, which can be used to "lead" the spectator.