My primate sense of fairness says that charging 100% of costs is actually a form of charity, 105% of costs is hyper-competitive, 110% of costs is quite respectable and meritorious, whereas 150% of costs is getting to be overly ambitious.

10000% of costs is, quite simply, asking for someone to put a shiv in your kidney.

The only way to achieve such margins is by literally suppressing all competition with armed force, with an unquenchable, non-substitutable demand. In the case of pharmaceuticals, the feds provide that force.

Feds provide force sometimes, but other times it's just a matter of time. When you produce a new product or service, you have a 'monopoly' on it until other people move in. Thus, margins start high and quickly lower even in a maximally competitive environment. Just wanted to share that concept in case others didn't make that connection!

That primate is sense is just that - namely, primitive.