The flavors must make some sort of difference. I have an e-cig. Not a huge user, but I notice that the resistors clog up a lot faster with the darker juices and last a lot longer with the clear ones. I am mildly concerned about the effects that they might have on health - because when I got it I had read stuff similar to your "two to three chemicals" line also saying that its essentially the same as an asthma inhaler, when the reality is somewhat different.