If they would be so advanced as you say, they would probably be conscious enough to be able to play any game asked. If that's the case, we could just create them outside of a game and ask them to play against humans. They would, sort of, role play as NPC or as an adversary. That would solve the problem of acting violently against them. They wouldn't get hurt, since they wouldn't be the suffering characters per se. They would just play the same game and understood the implications.