Not as long as amazon is perfectly willing to do a refund when you receive a product that wasn't as-advertised. And i haven't seen any evidence that amazon is unwilling to give a refund.

Not only will doing a chargeback destroy your amazon account, issuing a chargeback without first asking for a refund is probably against your credit card's ToS. A chargeback should be a measure of last resort, not the first solution you jump to.