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Re:Cultural differences may leave their mark on DNA by tristor on Tuesday January 10, 2017 @12:15PM (#13366567)
Looks like the TL;DR conclusion is that "race" is not just a social construct, but actually has genetic markers which are expressed beyond ethnic heritage. As the authors conclude, this could be extremely important in tailoring medical treatments for people for differences in their genetic makeup based on their race. In other words harder sciences are proving that social sciences obsession with identity politics has hindered medical advancements once again.
Re:Cultural differences may leave their mark on DNA by ChemicalWarfare on Tuesday January 10, 2017 @01:04PM (#13367150)
"Race" has 2 meanings.

1. Race as a social construct. It does exist in that capacity - as an extreme example Irish were not considered "white" in America (google for some "hilarious" images from "back in the day").

2. Race as a biological reality. This is a touchy subject for a variety of reasons. But that doesn't mean that well documented taxonomic differences between human races are "fake". They do exist and are more than "skin deep" - things like bone density, cranial capacity, maturation etc etc. Ask your dentist if he can tell by looking at someone's jaw x-ray whether it belongs to an east asian or sub-saharan african.

Re:Cultural differences may leave their mark on DNA by danharaj on Tuesday January 10, 2017 @01:26PM (#13367412)
What does it mean for "race" to be a "biological reality"? Interpopulation diversity of both phenotype and genotype isn't remarkably different from intrapopulation diversity. There are no genetic markers that taken together say "this person is black" or "this person is white". The concept of race was never grounded in real science and its proponents constantly change their justifications after the fact. At one point the "biological reality" of race was said to be rooted in phrenology.

Race is not just a word for different breeding populations of humans. The dilution of its meaning into something so innocuous is ahistorical, in fact it contradicts what was claimed to be the reality of race just decades ago. It's a political concept first and foremost.

No biological theory predicts races. Races are categories rooted in historical economic exploitation and domination that are a posteriori fitted with whatever truthy pseudoscientific justification is catchy at the time. Any categories of humans that biological measurements would come up with would hardly match racial categories. Perhaps the most racialized group that has distinct biological markers are Ashkenazi jews. However, the relation between Ashkenazi jews, Sephardic jews, and ethnic Arabs is very strong.

P.S. A review of the legal history of race in colonial America: https://sph.umd.edu/sites/default/files/files/Harris_Whitene...

Re:Cultural differences may leave their mark on DNA by marchenko on Tuesday January 10, 2017 @03:03PM (#13368422)
"Race" is more of a sociopolitical idea with a particularly noxious history, but human groups with differentiable shared recent ancestry - while fuzzy - do exist. Because "race" can be described as a continuous distribution, it helps to think about it probabilistically: there are no "definitely Caucasian" SNPs, but we do have suites of what we call Ancestry-Informative Markers that can be use to infer the likelihood that someone belongs to a particular ancestry group. Perhaps unsurprisingly, many of the polymorphisms associated with pigmentation are informative in this regard. The fuzziness of the continuum means that it is quite possible to define an arbitrary number of "races", depending on your chosen criteria. And admixture at multiple points in history further complicates the picture. But it is possible to discern biogeographical mappings within a generous error margin. As the parent poster points out, these mappings sometimes conflict with the those that we've constructed out of ideological convenience.
Re:Cultural differences may leave their mark on DNA by cb18 on Tuesday January 10, 2017 @02:06PM (#13367861)
There are no genetic markers that taken together say "this person is black" or "this person is white".

Actually, there very much are.

I think what you're trying to say is that not all black people have all the "black people genetic markers," and likewise for other groups. This is true, but this is not necessary to distinguish well-defined groups.

Family resemblance is a philosophical idea made popular by Ludwig Wittgenstein

It argues that things which could be thought to be connected by one essential common feature may in fact be connected by a series of overlapping similarities, where no one feature is common to all.

https://en.wikipedia.org/wiki/Family_resemblance

Re:Cultural differences may leave their mark on DNA by ChemicalWarfare on Tuesday January 10, 2017 @01:46PM (#13367633)
>>>What does it mean for "race" to be a "biological reality"?

to quote my own post - well documented taxonomic differences between human races.

Re:Cultural differences may leave their mark on DNA by r00fus on Tuesday January 10, 2017 @03:18PM (#13368552)
At what point does someone become "black" or "asian"?

Or are you talking about biological differences as they correlate with geographic locality?

Re:Cultural differences may leave their mark on DNA by SilasX on Tuesday January 10, 2017 @03:47PM (#13368822)
You can play Sorites Paradox[1] with anything; doesn't mean the categories don't exist, or that they don't carve reality at important joints.

"Heaps don't exist because you can't prove an ironclad boundary between heaps and non-heaps."

"Tallness isn't a thing because you don't have a firm, binary definition of when someone is tall."

[1] https://en.wikipedia.org/wiki/Sorites_paradox

Re:Cultural differences may leave their mark on DNA by qntty on Tuesday January 10, 2017 @01:38PM (#13367553)
This is really insightful. Can you recommend any books to introduce thinking critically about race?
Re:Cultural differences may leave their mark on DNA by danharaj on Tuesday January 10, 2017 @06:22PM (#13370234)
There's many different angles to approach the topic from. I added a link to my post providing a legal point of view. Law is an excellent historical record in many ways and it provides a window into what the ruling class thought of race. Here's a book with a much wider scope that requires a little ambition to read: https://eserver.org/Clogic/1-2/allen.html

I am hesitant to recommend it because I have not read much critique of its central points. But I think it's good.

Re:Cultural differences may leave their mark on DNA by svachalek on Tuesday January 10, 2017 @01:20PM (#13367349)
What I understand of the issue is that genetic differences between populations are real, but they form a continuum whose boundaries are extremely blurry if visible at all from a genetic level. Thus the drawing of boundary lines and the assignment of individuals into those handful of categories is something subject to change from culture to culture. In other words, genetic differences do not make race a "biological reality".
Re:Cultural differences may leave their mark on DNA by fvdessen on Tuesday January 10, 2017 @01:44PM (#13367614)
If you do a clustering analysis on a large sample of DNA data you will get different clusters corresponding to the usual definitions of races or ethnicities, depending on the number of clusters you choose.

https://en.wikipedia.org/wiki/Human_genetic_clustering

Re:Cultural differences may leave their mark on DNA by openasocket on Tuesday January 10, 2017 @02:02PM (#13367809)
That wiki page has a pretty substantial "Criticism" section. The Rosenberg et. al. paper even says their paper "should not be taken as evidence of our support of any particular concept of biological race." Their study shows that genetic distance is roughly linear with physical distance, barring obstacles like mountains and oceans. The consensus in the field, based on citations on that wiki page, seems to be that human diversity is a continuum, so any dividing lines you try to make to partition it will be largely arbitrary. It's like looking at a rainbow at trying to divide up the yellow from the orange from the red and so on: you can do that, but your color categories don't completely capture the spectrum visible.
Re:Cultural differences may leave their mark on DNA by fvdessen on Tuesday January 10, 2017 @02:34PM (#13368137)
You can make meaningful and consistent groupings in a continuum . For example you can make a distinction between poor and rich citizens, even tough the income distribution is a continuum. Same goes for the rainbow, the fact that it is continuous doesn't prevent people from being able to differentiate yellow and blue.

But even so the human genome is not continuously distributed, even if the difference is linear with distance, simply due to the fact that humans are not continuously distributed geographically. You can't handwave oceans and mountains away.

The main criticism of clustering is that the hierarchy of clusters that you obtain depend on the distribution of your samples, and that we currently do not have a good uniform sampling of human DNA. In short clustering can tell you reliably if someone is Irish or Italian, but may falsely identify the french as italian if there are not enough samples for french people.

Re:Cultural differences may leave their mark on DNA by wnoise on Tuesday January 10, 2017 @01:27PM (#13367438)
They're not visible at the level of looking at one SNP at a time. If you look at a whole lot of genes, you can get a very good idea of race.
Re:Cultural differences may leave their mark on DNA by ChemicalWarfare on Tuesday January 10, 2017 @02:10PM (#13367891)
Just because there's "color brown" doesn't mean there's no "red" or "green" used to produce it even if (hypothetically) in someone's culture "brown" is considered to be "red-ish" :)
Re:Cultural differences may leave their mark on DNA by WikipediasBad on Tuesday January 10, 2017 @12:22PM (#13366650)
How did you come up with that? Did you even understand the article? It is quite literally saying social/cultural changes leave an impact on genetic transcription of DNA through methylation and epigenetic markup. In fact, this proves just the opposite. That social factors are intricately tied to genetic output. What this proves false are the hardliners of each side of the debate that espouse race is a purely social construct, and the other end that naively call race a simple set of genetic traits.
Re:Cultural differences may leave their mark on DNA by openasocket on Tuesday January 10, 2017 @12:32PM (#13366760)
To pick a nit, technically this article demonstrates race is a social construct, but social constructs affect gene expression.
Re:Cultural differences may leave their mark on DNA by tristor on Tuesday January 10, 2017 @12:31PM (#13366752)
I am not a geneticist, so perhaps I misunderstand, but the conclusion I formed seems to be reinforced by the quotes from the authors in the article. That is, there are specific gene expressions which are relevant in a medical context affected by cultural factors that are genetically transmitted. Genetic transmission at least to me implies that a person receives these things from their parents at birth, regardless of their own specific upbringing, because of cultural factors of their parents upbringing, and so on. As in, cultural differences can be expressed over time as genetic differences.

“These data suggest that the interplay between race and ethnicity as social constructs and genetic ancestry as a biological construct is more complex than we had realized,” said Noah Zaitlen, PhD, a UCSF assistant professor of medicine and co-senior author on the new study. “In a medical context both elements may provide valuable information.”

Setting aside the fact that this is such a touchy issue that the authors are carefully couching their language, it looks like there may be ways in which this new information can help people by tailoring medical treatments. I'd love a ELI5 explanation of this if I'm somehow misunderstanding, but the conclusion I formed seems to be supported by the article to my reading of it.

Note, I'm not taking a hardline stance. That's why I said "race is not just a social construct" in my conclusion.

Re:Cultural differences may leave their mark on DNA by openasocket on Tuesday January 10, 2017 @12:49PM (#13366983)
Gene expression is partially inherited and partially a product of environment. See https://en.wikipedia.org/wiki/Transgenerational_epigenetic_i...

The classic example discussed is a study of children born during a famine. Children born during famine are going to be smaller than normal, but it was found that their children and grandchildren would be born smaller than normal, even though the famine has long since passed. This change has been attributed to a particular methylation pattern that was passed down.

It's known that things like exposure to famine and abuse can change methylation patterns, but this study suggests that non-traumatic things like your cultural upbringing can affect methylation.

Re:Cultural differences may leave their mark on DNA by tristor on Tuesday January 10, 2017 @02:54PM (#13368329)
Thanks for the link. I read that, it seems to support my conclusion of this article as well. "As in, cultural differences can be expressed over time as genetic differences."

It seems like the debate we're having is a rehash of nature vs nurture, where it seems like the new research indicates nurture can affect nature for future generations through gene expression.

Re:Cultural differences may leave their mark on DNA by 4rtemis on Tuesday January 10, 2017 @12:41PM (#13366882)
I feel like biological populations can be reduced down to one individual and up to all of humanity. You can attempt to make logical decisions about where to draw these lines in between, but you'll get overlapping populations at different levels given different traits. These epigenetic flags are not dissimilar to genetic traits in that no one, nor group of them unequivocally define an individual into a biological group except if that group is "organisms that express this trait". It definitely won't square cleanly with our social macro-constructions around "race".
Re:Cultural differences may leave their mark on DNA by hx87 on Tuesday January 10, 2017 @12:31PM (#13366758)
Biological populations certainly do exist, it's just that they don't correlate well with prevailing concepts of "race". The average western African is more similar to the average European than to the average southern African.
Re:Cultural differences may leave their mark on DNA by erispoe on Tuesday January 10, 2017 @12:55PM (#13367033)
Populations in Africa are also genetically more diverse than the rest of the world combined.
Re:Cultural differences may leave their mark on DNA by lacampbell on Tuesday January 10, 2017 @01:19PM (#13367329)
But people are ignorant of Africa in general. When they talk about an African race they're ignoring Ethiopians or khoisans or pygmies - they mean Bantu people.

I don't think there's more genetic diversity among Bantus than the rest of the world combined.

Re:Cultural differences may leave their mark on DNA by hx87 on Tuesday January 10, 2017 @01:31PM (#13367470)
> But people are ignorant of Africa in general.

Not population geneticists. Africa in those cases == sub-Saharan African people, not just Bantu.

Re:Cultural differences may leave their mark on DNA by lacampbell on Tuesday January 10, 2017 @01:12PM (#13367246)
Source? By southern African do you mean Khoisan?
Re:Cultural differences may leave their mark on DNA by hx87 on Tuesday January 10, 2017 @01:32PM (#13367485)
Here's one paper. By southern African I do mean Khoisan as well as related peoples.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953791/

Re:Cultural differences may leave their mark on DNA by lacampbell on Tuesday January 10, 2017 @01:39PM (#13367563)
Would the layman consider Khoisan and Bantu people to be of the same race? I mean after learning about the existence and names of both of them.

I am a layman who knows next to nothing about genetics, but a bit about Africa, and I would not consider the two peoples to be in the same race. They look completely different - which is what most laymen use to determine race, isn't it?

Re:Cultural differences may leave their mark on DNA by Impossible on Tuesday January 10, 2017 @03:14PM (#13368519)
I think a layman, at least in the US and countries that define race in similar ways as it is defined in America, would consider Khoisan and Bantu people the same race (black), even if they knew they were different groups. African Americans in the US often look different but are all considered "black".
[dead]
Re:Cultural differences may leave their mark on DNA by hx87 on Tuesday January 10, 2017 @01:33PM (#13367499)
Please elaborate or hold your peace.
Re:Cultural differences may leave their mark on DNA by stcredzero on Tuesday January 10, 2017 @01:35PM (#13367512)
Looks like the TL;DR conclusion is that "race" is not just a social construct, but actually has genetic markers which are expressed beyond ethnic heritage.

That's not how I read it. My takeaway was that "race" is a social construct that can leave epigenetic markers. In other words, culture can affect physiology.

In other words harder sciences are proving that social sciences obsession with identity politics has hindered medical advancements once again.

I would agree that many in the social sciences create epistemological problems for ideological reasons.

Re:Cultural differences may leave their mark on DNA by winter_blue on Tuesday January 10, 2017 @12:22PM (#13366647)
Actually the genetic differences between races are far smaller and more blurry than most people would imagine (based on differences in appearance).

The Atlantic had an article about exactly the kind of thing you're taking about, and how this kind of pseudoscience is being pushed by neo-nazis and the alt-right: http://www.theatlantic.com/amp/article/510962/

Re:Cultural differences may leave their mark on DNA by tristor on Tuesday January 10, 2017 @12:35PM (#13366798)
Thanks for once again proving that nobody can ever have a serious discussion about science related to ethnicity because someone will always jump up, point at them, and scream "racist". I wonder if it's occurred to you how many people suffer from medical conditions because they're either untreated or treated poorly because we don't bother studying and reporting on things like this, specifically and exactly because there's a hundred people just waiting in the wings to call you a racist for studying it?

Nothing in the article is racist, nor is anything in my statements. Please take your ad hominem elsewhere.

Re:Cultural differences may leave their mark on DNA by openasocket on Tuesday January 10, 2017 @12:55PM (#13367040)
I think he's responding to the line "harder sciences are proving that social sciences obsession with identity politics has hindered medical advancements" which I would consider false. The existence of genetic diseases that are largely present in a single race has been known for a long time. Tay-Sachs is seen almost entirely in Ashkenazi Jews, Sickle Cell is mostly seen in Africans, etc. I don't think "identity politics" is rejecting this notion, or if it is it's doing a bad job of it.
Re:Cultural differences may leave their mark on DNA by notahacker on Tuesday January 10, 2017 @02:54PM (#13368331)
To be honest, it's equally difficult to have a serious discussion about science related to ethnicity when people insist on using an interesting piece of research as a launchpad to make tangential and evidence-free claims that social science is harming serious research, regardless of whether they actually harbour any sympathy for the viewpoints of your garden variety racist or not.

At the time of this article only two of the many subthreads related to this article had descended into politics and name-calling. One was initiated by your very own unsubstantiated attack on "identity politics". The other (considerably less favourably-received) post was claimed the notion of a social element to race that was the work of "lunatics and agitators seeking to attack and disrupt western society" and argued the researchers were doing themselves and society a disservice by engaging with it. Remind me who it was that's putting a negative slant on useful medical research again.

Re:Cultural differences may leave their mark on DNA by tristor on Tuesday January 10, 2017 @05:08PM (#13369604)
I'll admit my snipe at the end about identity politics was inflammatory, but it's specifically because of my frustrations trying to have any sort of serious discussion about these types of topics. People immediately throwing out the racist card and comparing you to neo-nazis for wanting to discuss the topic is /exactly/ what I mean by "identity politics" although its just one of the more pernicious subsets. My attack on "identity politics" is substantiated by my own experiences and a significant body of philosophical work, but probably this is not the appropriate forum for it.

As a side note, when I started my thread there were more than 60 upvotes on the article and no comments. At least there's a discussion.

Re:Cultural differences may leave their mark on DNA by samudrin on Tuesday January 10, 2017 @01:00PM (#13367105)
Actually my read was that environment can influence epigenetic markers, and that environment is measureable in aggregate based on ethnicity - in this study.

The study does not compare other groupings of people who share a common environment and the influence on their epigenetic markers.

It says nothing about identity politics.

Re:Cultural differences may leave their mark on DNA by alistproducer2 on Tuesday January 10, 2017 @01:42PM (#13367592)
It's pretty clear you skimmed the article and read from it what you wanted, instead of what it actually said. I read through the responses and you've been pretty thoroughly proven wrong so I won't reiterate the points.

Constructively, try not to see news as a chance to reinforce your existing views. Try and do the opposite. try to expand your world view.