Moving at 100 mph in a car does not seem exactly natural either.

My lizard brain disagrees with you.

A "lizard brain" (besides being a hypothesis largely dismissed by neuroscientists) seems unlikely to have any reference point or other handling for "I'm sitting in a tube 30,000 feet up at 700mph". Similar to how we're basically incapable of thinking about numbers like a billion dollars effectively.

Interestingly there is a great deal of work that weather services, air traffic control, and pilots do to avoid turbulence for this exact reason.