Unfortunately, the modern interpretation of "interstate commerce" is roughly "any other powers they might care to have". The Tenth Amendment has essentially been superseded by the Commerce Clause since the New Deal.
US states were intended to be semi-autonomous regions which reflected cultural distinctions of residents inhabiting the original colonies. The different "flavors" of American culture have more or less persisted, even in today's mobile population there are still nuances that make the cultures of states unique.
That's wishful thinking. The President-elect has already announced reforms heretofore considered well beyond the President's legal authority.
The commonly-heard Republican slofan of "States' Rights" is only heard when Democrats are in power. (And likely vice-vers