A significant subset of people in the US insist the federal government has overstepped its powers, using "interstate commerce" to inappropriately expand federal authority. With the forthcoming change of federal government, in the years ahead it's likely there will be some paring back of federal overreach. Whether that's a good or bad development remains to be determined.

US states were intended to be semi-autonomous regions which reflected cultural distinctions of residents inhabiting the original colonies. The different "flavors" of American culture have more or less persisted, even in today's mobile population there are still nuances that make the cultures of states unique.