I haven't heard of ChREBP before. Is it something that has been well known in the research community for awhile? Has there been consensus as to its role in the disease pathway, or is it recent?

(I took two semesters of immunology in my biochem undergrad--courses that I would have expected to cover this. I was never exposed to literature or material on this protein. I also haven't heard of it in the primary literature I do occasionally still read.)

The most major finding, which appears to be this:

> The study found that fructose initiates a process that causes the liver to keep making glucose and raising blood glucose levels, even as insulin tries to keep glucose production in check.

Is not ground-breaking. It's how the liver metabolizes fructose. The liver can't respond to insulin because it needs to metabolize the fructose.

I don't think that's fair. This is just a press publication; we'd need the actual paper to see what its specific claims are. Besides, very little in science is "ground-breaking" at first. Scientific progress happens most often through an accumulation of evidence over time.