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Re:Show HN: Mobi.css – A lightweight, flexible CSS framework... by pritambarhate on Sunday September 04, 2016 @06:33AM (#12423681)
This depends on flexbox. As per CanIUse flexBox is fully supported only on Android 4.4 and above.

However as per:

https://developer.android.com/about/dashboards/index.html

More than 20% "active" Android devices out there still don't support flexbox. So unless you are targeting websites only for high end device owners, flexbox only is still not an option.

Edit: Posted it too fast! On CanIUse I checked support for Android Browser. However Google Chrome for Android is supported on 4.1 and above. So most likely many Android users running Android 4.1 to 4.3 may be using Google Chrome. However it's hard to know how many.

Re:Show HN: Mobi.css – A lightweight, flexible CSS framework... by skrebbel on Sunday September 04, 2016 @07:27AM (#12423798)
Also IE9, which is used by many people, especially at work, who's computers are stuck on Windows 7.
Re:Show HN: Mobi.css – A lightweight, flexible CSS framework... by ergo14 on Sunday September 04, 2016 @08:00AM (#12423892)
All browsers lower than IE11 are NOT supported by microsoft and are a security risk. People should not support them, a lot of websites like youtube and others will not really function correctly in them.
Re:Show HN: Mobi.css – A lightweight, flexible CSS framework... by carc1n0gen on Sunday September 04, 2016 @07:33AM (#12423814)
This is targeting mobile specifically