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Murfalo

Welcome to publications involving ML in 2026... Glad to see someone else write this though because it's important to start having these discussions. Too much overselling has been happening for too long. There is so much great about ML. IMO it hurts the field to continue overselling claims like this.
McCarthyism on the menu? Why, Cold War II is already being served! Hurry up, it's getting... cold : o
Re:GLP-1 may slow biological aging on Sunday October 18, 2026 @06:16PM (#50146052)
A few examples. Eli Lilly (Zyprexa): $36B sales vs. $1.4B fine, Pfizer (Bextra & others): $16.8B vs. $2.3B, Pfizer (Neurontin): $2.12B vs. $430M, Johnson & Johnson (Risperdal): $10.8B vs. $2.2B, Amgen (Aranesp): $7.4B vs. $762M, GlaxoSmithKline (Paxil & Wellbutrin): $9B vs. $3B

Wonder where GLP-1s will end up

Re:GLP-1 may slow biological aging on Sunday October 18, 2026 @06:07PM (#50145980)
Interesting hypothetical. Let me know when you've got one, can't wait
Re:GLP-1 may slow biological aging on Saturday October 17, 2026 @01:05PM (#50132864)
Let's play spot the conflict of interest. Three of seven authors tied to a company selling biological aging tests. One consults for Merck, GSK, etc.

There seems some promise at times but I also struggle to see the recent slew of "GLP-1s cure X", where X is seemingly any ailment known to man, as much more than the next Big Pharma gold rush where the profits dwarf any eventual regulatory fines, and taxpayers and real patients are left with the costs.

Re:Amazon pushes up prices across the Internet on Wednesday October 14, 2026 @08:54AM (#50086974)
Same. I'm in the US and do not use Amazon at all. Life, and the products I buy, actually got much better. Amazon is overpriced and low quality. Pretty much everywhere else has better products, lower prices and free & fast shipping at this point (Walmart, Target, Home Depot, direct purchases, etc.). Pretty shocked at all the people defending Amazon here.

Ask HN: What if we funded math research like we fund AI labs?

The annual U.S. federal budget for basic math research is <$1B.OpenAI alone just raised ~$122B, and frontier labs are increasingly concentrating enormous amounts of compute and human talent on open math problems.We seem to be entering a strange situation where a handful of private labs have vastly more resources for attacking these problems than the academics traditionally responsible for...

( Read More... | 1 comment | 2 points | on HN )
Re:LLMs as a Cognitive Virus on Sunday September 06, 2026 @10:54AM (#49587065)
Fair, I may have tried too hard to see the other side of the argument! Sensitive topic of course, but definitely one of the clearer cases where "just put the book down" has not always an entirely available option.
Re:LLMs as a Cognitive Virus on Saturday September 05, 2026 @08:46PM (#49582270)
Tipping points and technological lock-in aren't new (e.g., the printing press, the radio, TV, phones, the internet, etc.). I do absolutely see your distinction, though, that prior technologies may have been less capable of imposing specific belief systems compared to frontier LLMs.

That's a fair point, and a key reason why competitive open models are so important. I definitely don't want to be stuck using Google's latest and greatest LLM once companies, marketers, and PACs can pay to subtly influence responses as they choose.

We've all seen this movie before, though.

Re:LLMs as a Cognitive Virus on Saturday September 05, 2026 @05:36PM (#49580929)
I love this line of thinking but the framing comes across to me as a bit inflammatory and uncharitable. Just about anything involved in the exchanged of ideas can be viewed as a virus! That is because, when viewed from an evolutionary biology perspective, ideas are the cognitive equivalent of genes (in fact, this is where the term meme comes from).

There's a whole field, evolutionary memetics, dedicated to this. Cultural values, marketing, religion, social media, education, propaganda, etc. can all be viewed quite naturally through this lense. Even the terms we use in every day language (eg, going "viral") seem to intuitively grasp this.

Is my friend a virus for recommending me their favorite book? Well, yes I guess, but that's kind of just how ideas work. Just my two cents

Re:Don't Wordle on Tuesday August 25, 2026 @12:12PM (#49436441)

    *      12974
    QAJAQ   1979
    PZAZZ    861
    OBANG    449
    URARI    232
    FLAFF     58
    DWALM     10
(totally didn't cheat: https://github.com/murfalo/dontwordle-assistant)
Obvious? How do you propose adopting and regulating the technology in a way that the public wants and that allows reasonable privacy?
Re:How to Exist on Saturday August 01, 2026 @10:25AM (#49134739)
Right, I think commonly "doing nothing"/meditation is approached with the goal of "doing something", i.e. "getting the hell out of here" or changing instead of sitting with how you feel in the present moment. And, just as you say, that basically defeats the entire purpose.
Simple trick for those outside of academia. Google the impact factor of the journal you are reading. If it's below 5 it's fake. If it's 5 or above, it's also fake.
> Is the mitochondria the powerhouse of the cell?

Chat paused. Fable 5's safety features have flagged this chat.

Help, it's 1 a.m. and I haven't eaten dinner!
Re:Don't YOLO your file system on Saturday March 28, 2026 @11:55AM (#47555730)
Alternatively, the "feel free to leak all my data but please use my GPUs and don't rm -rf /" config:

  {
    "sandbox": {
      "enabled": true,
      "filesystem": {
        "allowRead": ["/"],
        "allowWrite": [
          ".",
          "/tmp",
          "/dev/nvidia0",
          "/dev/nvidia1",
          "/dev/nvidia2",
          "/dev/nvidia3",
          "/dev/nvidia4",
          "/dev/nvidia5",
          "/dev/nvidia6",
          "/dev/nvidia7",
          "/dev/nvidia8",
          "/dev/nvidiactl",
          "/dev/nvidia-uvm"
        ]
      }
    }
  }

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