Some of the charities mentioned are clearly advocating for policy change (lifting copyright and restructured tax schemes), and I think that generally all charities must decide how to relate to the current structure of the world because whatever the ill you are campaigning against preventive measure are most effective at preventing suffering. So one question is if you see any natural limit for when something goes from a charity to a political campaign and vice versa. For instance, imagine the bizarre scenario where a presidential candidate pledges a significant increase to foreign humanitarian aid by taking from the foreign military aid budget. Will make that candidacy a worthwhile charity (supposing the bizarro candidate has reasonable probability of winning)?

An unrelated question is: why do you think there are so few investment opportunities that are truly concerned with being ethical? The GiveWell founders seems like they could have made an investment fund dedicated to growing local companies in the poorer parts of the world. Direct cash transfers are among the best ways of helping the poor, but stable financing with modest return expectations seems like it could be pretty good too, with the benefit of slightly growing the capital available to help. Or you could imagine getting a significant amount of shares in Shell and turn up at shareholders meetings and make them repair their pipelines properly and such things.