I am rather amazed nobody has mentioned LyX yet. Its "what you see is what you mean". You get the pointy-clickety GUI, all the tweaking possibilities you need, and you can still simply focus on content, ignoring the jibber{jabber} until you really need the ERT (evil red text). When it's time to layout, you let LaTeX do all the work.

http://www.lyx.org/Home