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Re:Ask HN: What startups are working on hard, technically ch... by IsaacL on Saturday March 21, 2015 @06:36AM (#9242358)
A few ideas below. You mention startups trying "to make as much money as possible as quickly as possible" - I personally quite strongly believe that companies that focus on long-term profitability also happen to do a lot of good for mankind.

- cure for cancer

- cure for malaria

- cure for aging

- cheap fossil fuel extraction from low-quality deposits

- safer nuclear fission

- nuclear fusion

- lower-cost space travel

- space elevator

- space colonisation

- intelligence augmentation

- safe artificial intelligence

- desktop nanofactories

- nano-machines

Re:Ask HN: What startups are working on hard, technically ch... by XorNot on Saturday March 21, 2015 @07:04AM (#9242401)
Of these, fission/fusion/fossil fuels are the only ones start ups might touch. And even there, it depends on a lot of physics turning out favorably.
Re:Ask HN: What startups are working on hard, technically ch... by saboot on Saturday March 21, 2015 @07:09AM (#9242412)
At least the Helion guys believe they have a good shot at it http://www.helionenergy.com/