So I've actually taken a look and tried to read through Durandal's docs -- I haven't actually used it in a project though (or even kicked the tires on it in a TODO app or something)...

I found the docs really hard to follow, and they seemed really complicated (and I didn't think it should have been)... It is entirely possible (and even likely) that I didn't put in much effort. But knockout (and tools like it) hit such a sweet spot for me because they are (almost) dead-simple.