It's possible in theory. I have customized my ABP rules a ton, switching off rules I didn't want (impossible in uBlock), adding targeted rules for anything from annoying animated avatars to slow domains or bloated mastheads you can't scroll past (shit's almost as bad as modal pop-ups), and I've been unable to do any of it in uBlock because it's way, way too much hassle.
You have powerful editing rules, so you could certainly tune all rules and lists to your liking: " List of your dynamic filtering rules.
Rule syntax: source destination type action. " followed by a GitHub wiki link to the doc.