http://en.wikipedia.org/wiki/Mixin#In_Common_Lisp
In RPG's inconsumerability essay [1], he describes it like:
> In that paper they described looking at Beta, Smalltalk, Flavors, and CLOS, and discovering a mechanism that could account for the three different sorts of inheritance found in these languages—including mixins from Flavors and CLOS.
They did come from Flavors first regardless (mixins being named after an ice cream shop with mixins near MIT, so I heard). I think it was also the first system to allow for aspect advice via a first-class construct.
http://lispm.de/docs/Publications/Flavors/Flavors,%20a%20non...
'aspect advice' was mostly introduced in Lisp in 1966 by Warren Teitelman: http://dspace.mit.edu/handle/1721.1/6905 See the discussion of ADVISE and a BEFORE example in the paper... From there it came to Interlisp, Maclisp, Flavors and CLOS...