Either way, between Cleveland, Robins, Few, and Ware there're tons of studies and references:
http://cm.bell-labs.com/cm/ms/departments/sia/wsc/index.html
http://www.researchgate.net/researcher/2028337238_Naomi_B_Ro...
http://www.perceptualedge.com/library.php
http://www.amazon.ca/Visual-Thinking-Design-Colin-Ware/dp/01...
Better is subjective though and related to what you're trying to do. A lot of past research was about efficiency of information transfer. There's more recent research looking at memorability. In one report, different graphics could have both goals.
There's a "Useful Junk" paper delving into that topic. There's a link to it in Few's reply: http://www.perceptualedge.com/articles/visual_business_intel...
There's plenty more. Stanford Vis group is a fun place to check from time to time: http://vis.stanford.edu/ Heer specifically has a range of papers and some online slides for a vis course he taught http://homes.cs.washington.edu/~jheer/ (uses Tufte for the course text)
I'm drawing a blank on a few others I find informative...
Unfortunately, I don't have any about fonts but I'm sure there are plenty out there.
[0] http://www.amazon.com/Design-Everyday-Things-Revised-Expande...
[1] http://www.amazon.com/Emotional-Design-Love-Everyday-Things/...
Would you say "launch" if you only saw the first 2 charts on this page:
http://www.asktog.com/books/challengerExerpt.html
Would you say "launch" if you saw the 3rd chart on that page?
The decision to launch tomorrow is yours. What do you decide?
But anecdote is not the plural of data. Pretty is not automatically effective.
Nielsen Norman Group occasionally hit some unusual exceptions when they actually tested their assumptions about web usability even though they got most of it right. I suspect the same with Tufte.
...I've never read any of his works (I'm not the OP), is that the best Tufte book to start with?
[0] http://www.amazon.com/Graph-Design-Mind-Stephen-Kosslyn/dp/0...
Tufte's stuff is very arty and pretty. But is there any scientific evidence that it is BETTER?
For example, do his font choices result in less eye fatigue?
As blowhardy as I find Nielsen Norman Group, they tend to back their web usability stuff up with actual data and analysis.