Personally I never used Python for anything other than glorified shell scripts and Websphere installations (after Jacl got replaced by Jython).
For everything else I prefer languages with type inference and availability of native compilers (AOT/JIT) in their toolchains.
How good is PyPy for production code nowadays?
Unless you are using CPython extensions, PyPy is usable as a drop-in replacement that's significantly faster in almost all cases. In order to notice any significant speed gain, the JIT needs a chance to "warm up" though, so on short running applications or on web applications for the first couple of requests PyPy can be slower than CPython.
I'm not quite sure what you mean? In any case, the compilation speed isn't really an issue (especially since we're talking about Rust, which last time I used it wasn't exactly fast).
Small stuff like this really bother some people and they fly off to Pythonland never to be seen again.