Yes. Your endpoint is liable to be in another country, so sites that sniff that might be affected (google defaulting the german, some youtube videos not playing because they don't have play rights in Vietnam, etc). Google also likes throwing captchas at in case you're a bot. And if you login to gmail, they'll assume you're being hacked and text you about it.

Actually, aside from google properties, I've only seen a couple sites respond negatively to tor (slashdot and some blog that banned everyone from even seeing content based on a spam block list of some sort)