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Re:Total darkness at night key to success of breast cancer t... by kolev on Tuesday July 29, 2014 @03:48AM (#8101124)
4g or 4mg? Natural amount of secreted melatonin is much less (< 1mg), you're overdosing with 4mg. I use 0.3mg Herbatonin, which is bioidentical natural form of melatonin from a plant. 10-20mg is therapeutic dose.
Re:Total darkness at night key to success of breast cancer t... by gojomo on Tuesday July 29, 2014 @05:15AM (#8101329)
I find it interesting that over-the-counter melatonin comes in pills ranging from 0.25mg up to 10mg - a 40X range.

I suspect some people just try whatever bottle they grab first, and may find either no effect, or unwanted effects (excess grogginess/nightmares), and never try another dose.

Re:Total darkness at night key to success of breast cancer t... by joeyspn on Tuesday July 29, 2014 @07:58AM (#8101751)
Sorry... typo, 4mg obviously. I know is "slightly" overdose (1mg/day is the recommendation here in the EU), but as I said I take it every now and then, because of stress and jetlag.
Re:Total darkness at night key to success of breast cancer t... by otl1248 on Tuesday July 29, 2014 @05:16AM (#8101331)
Any bio-availability studies on that? I assumed the high doses were because uptake was bad / it was destroyed by stomach acid.
Re:Total darkness at night key to success of breast cancer t... by kolev on Tuesday July 29, 2014 @05:23AM (#8101343)
The whole "bioidentical hormones" thing some describe as unscientific, but I've been taking 10mg synthetic without knowing I've overdosing (that was the most popular OTC dose) with no effect. 0.3mg Herbatonin works pretty quickly. Here's something I just found: http://www.naturalhi.com/media/custom/Newsletter%20Melatonin...