Or, if you want to calculate probabilities, assume that a billion urls are used (this is an astronomic overestimate). That's 10^9 urls. The chance of hitting one of those with a random guess is 0.00000000000014% (if I counted the 0s right). Not very likely.
Now if the url is observed in transit - that's a completely different thing. Just don't think that random guessing is going to reveal this. It's similar to people thinking you can guess your way to product keys for software (hint: you can't).
Potentially true if you've chosen to upload with the 'one download' expiry time set, and then whomever you've shared the link with does not use it within 30 days (at which point it is expired & deleted). With the 'two days' option, the link does not become less secure than it was at generation because it (and the content) is deleted forever after 48 hours.