Re:Immunity Project – HIV Vaccine Development Program [pdf]
by shiven on Monday January 27, 2014 @10:32PM
(#7135149)
Thanks for answering with a reference!
I am not asking about the peptide sequence, just the protein it is derived from. But, if you cannot share that right now, that's OK too. I'll look out for the publication.
However, assuming I am making an educated guess about the parent protein, I'd go with gp120/gp41 envelope (env). I may be totally wrong there and you guys may have another ace up your sleeve (do hope so, fingers crossed!). Good luck!
Re:Immunity Project – HIV Vaccine Development Program [pdf]
by reidrubsamen on Tuesday January 28, 2014 @12:08AM
(#7135449)
Thanks very much for the kind note! I would be happy to send you a link to the paper the guys working on the statistical analysis of beneficial HIV target regions when it is published.
The targets we are trying to immunize with are believed to be beneficial by a statistical analysis similar to what is described here: Mothe B, Anuska L, Ibarrondo J, Daniels M, Miranda C, Zamarreno J, et al. Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of Translational Medicine 2011;9(208):20.
The guys who generated the peptides we are using have specifically asked us not to talk about the sequences because they are trying to publish now. We hope that these targets will be conserved to the point that resistance is limited (as may be the case in some HIV controllers) - won't know without clinical data.