My biggest issue with all of the frameworks is their lack of maturity. If you're working on a large platform with a team of people, you're going to want database migrations, localisation/i18n, asset management, proper testing framework, continuous integration and general proof of scale.

Meteor.js seems great but is still a bit of a gimmick in my eyes. But If I'm pressed to pick one, I have to say I'm much more interested to see what happens with Go and web frameworks like martini.