The exceptions, where I don't go straight to Amazon, are very specific, and are a handful of vendors that ship as quickly as Amazon and that I go to for specific ranges of products (e.g. my supplements).
The only times I'll comparison shop, and where Prime doesn't come into it at all, is for really big items. E.g. my TV (but the TV before that was from Amazon...). My last laptop (but the two before that were from Amazon).
Although Amazon has started it to do it themselves directly via "Amazon Warehouse Deals" -- http://www.amazon.com/b?node=1267877011 -- They'll actually purchase other seller's underpriced inventory and relist it themselves for a tidy profit. Especially easy when it's sitting in their warehouse already in a box.
I don't think anyone thinks such behavior would be morally alarming... but that's certainly a common perspective when it comes to high-frequency stock trading. What makes the difference?
I think #2 is actually the real reason people are up in arms about HFT, honestly. It's new, scary, and allows corporations to extract money seemingly from nowhere.
1. I don't understand phenomenon X
Therefore,
2. Phenomenon X must be stopped
To your point #1 in particular, it's true that normal people don't have access to HFT equipment, but they also don't own warehouses full of third-party goods (and would find those probably more difficult to obtain), so it's hard to explain in those terms why Amazon's hypothetical maneuver is different from HFT.
search compare prices on bikes brings up no comparison sites
search compare prices on laptops brings up 2 comparison sites (one result per site)
search compare prices on watches brings up 3 comparison sites (one result per site)
search compare prices on software brings up 2 comparison sites (one result per site)
Problem is comparison sites spam the search engine listings pretty hard. It's only a matter of time before Google decides to do something about it...
Generally, the bootstrapper focuses on building a sustainable business early on (whereas the VC-funded startups try until the wellspring dries up)
There may be a micro niche of price comparison within Amazon, because some rare / specific products are sometimes sold at wildly different prices on Amazon (and listed many times; not just different prices under the same listing).
And of course Amazon's search engine is completely broken; an actual product search, limited to Amazon, that worked would add tremendous value.
Personally, I'd find it a pain if a price comparison website diverged from their core search offering. Sites like [1]PriceGeek still have price comparison front and centre - much more useful for me as a consumer who can't tap into the benefit that Amazon provides.
There's still room for price comparison, just maybe outside of the US.
Just using amazon for all purchases makes it all a little easier.
But I also gave up on the website to build a browser extension. Shoptimate is bootstrapped and mainly active in Europe so I can execute more slowly and without the pressure of VC-money. But even then, it's a tough space.
I started a similar company, Shopobot. We launched, raised, got good press. Things looked great!
Shortly after we watched as Decide and Priceonomics launched.
After months of beating our head against the wall, we came to the conclusion that we weren't competing against Decide and Priceonomics. We were competing against Amazon.
Everyone we talked to loved the idea. But we found their praise didn't turn into clicks. We'd ask them why, and they'd always say, "oh, I just went to Amazon."
One day our lead dev was telling me about a recent purchase and I asked him if he used our site to find a good price. "No, I just used Amazon. I have Prime." That's when I knew we were fucked. Competing against Amazon without a really really strong value prop is not easy.
We've long since pivoted, Decide shut down, and now Priceonomics is perhaps pivoting. I think CamelCamelCamel is still at it! After all the VC money flushed out, the bootstrapper is still standing. :)
This reminds me, I have a long blog post to finish about how comparison shopping and price guides are difficult to pull off.