First off I was using one of those chest mounted hart rate monitors to mesure this and I am not dead. Second work = F * D ignores the increase in efficency's that your tendons provide. I can swing 2,000 lb 10 feet at the end of a long cable and not use much energy. However, lifting 600lb .5 secound pause, drop it 18 inches, .5 second pause, lift it is much harder because your tendons can't store as much energy for the next push. But, in running each stride you only need to add enough force to compensate for the inificency of the stride which is far less than the energy needed to lift your body that same distance verticaly.

Still, when you reach the limts on how fast you can move the body you can still aproach the same numbers, a 100kg person running at 10Mph for 60 min can still burn around 1020 calories. But, again your force is not your weight.

However, running involves a lot of inpact strain on the body and tends to lead to long term problems.