Something either browser-extension or mobile app would be a lot better. IMO, also not supporting legacy stuff like aim/yahoo/etc, and supporting OTR out of the box.
Nadim did a decent job on the simple UI front. I don't know about the lack of persistent identity (pluses and minuses to that).
Mobile is probably more important in the long run, especially for the kind of activist users CryptoCat seems to target.
(Another obvious thing is just i18n/l10n for arabic/pashto/etc., of existing tools.)
Another feature which would be nice is Grugqian "anti-forensics"; Adium for a while logged OTR chats by default, and even retaining OTR keys could be used against you (even if it doesn't allow decryption of past messages, it is enough outside of a court of law to link you to activity...). A browser extension or mobile app which didn't save local state (doing key derivation from a passphrase?) would probably be great for that. Add in SnapChat-style "no logging in the application", and honest-but-stupid counterparties wouldn't log chats.
The only weakness I see is no great way to do message-encryption for multiparty right now in a standard way. I'm not sure how you can do multiparty key agreement with PFS using anything outside academic papers.
Or with a trusted third party (at the limit, just do irc-over-SSL.) This is probably fairly safe if you pick your TTP correctly -- I'd trust the NYT or USG even if I were a Syrian protester with the FSA.
I agree overall -- and am not trying to defend CryptoCat, just the CryptoCat market niche.