Deadpool's breaking of the 4th wall typically makes him to be considered insane by the other characters. But other Marvel characters have broken the 4th wall to their advantage so it stands to reason it could be listed as an ability of some sort.

I believe there are examples on the DC side as well. I've always felt that the Joker understood he was a comic book character so that it doesn't matter what he does as none of it is real.