He means that you should hire unbalanced workaholics, that meteoric success is more important than providing a good, sustainable life for yourself and your employees.

It's like saying "that person is a machine." They are able to sustain a high level of work output. Think of an ox tirelessly tilling a field.

I think nowadays he says 'relentlessly resourceful' instead.

He is saying disregard personal hygiene deficiencies.

Likely he means, "totally committed, focused and in the moment", like a party animal, and without existential doubts about being in your startup.