This is what it is for me too. For the last several years I've used Zoloft on and off and it helped me a lot. However, after the most recent episode hit back in February/March, I decided to try a nutritional approach. I've been seeing a therapist who specializes in this am about three weeks into a pretty extensive supplement regimen. It seems to be working.

Part of my problem relates to alcoholism. The therapist says alcohol and other depressants have a depleting effect on nutrition.