Heh, way back when I wrote a 3d game in Gambit Scheme, but I'm not shipping it anymore. There are definite drawbacks, but pretty big wins too. I set up a live REPL to the phone and was able to send code straight from Emacs to it.

My original article is here: http://jlongster.com/s/jlongster-old/pages/blog/write-apps-i...

I also made a bunch of videos:

https://www.youtube.com/watch?v=Q7c0rU9Lv28 https://www.youtube.com/watch?v=Fcut5__ZrSg

There are hurdles, yes, as you will find with any "off the beaten path" technology stack. Lack of documentation, small community, etc.