I have a feeling that there is great deal of buggy software in biology. Taking non-scientific software for example such as Rails, if there is a bug this becomes obvious a page is loaded incorrectly or a model is pulled incorrectly from the database.

In contrast imagine an academic scenario where I'm testing a hypothesis using someone else's software. How do I notice a bug? I'll notice the bugs where the output is in the wrong format for example. More subtle bugs I won't notice because I don't have any expectation on the results. This will affect the conclusion I draw though.