I think it depends strongly on your target market. If you're building B2B enterprise software used exclusively on PCs on a desk, in an office, with no remote access, the mobile might be less important.

thats a very narrow market me thinks?

also, the sort of enterprise you speak of would certainly not be purchasing software like these - they'd stick with the trusted and known big name vendors. As they say, nobody ever got fired for using IBM (or microsoft).

It's not impossible to get your foot in the enterprise door, I've built several solutions for one particular client.

If you've got a contact who trusts you then you could certainly pitch solutions to them, and the prices you can charge are a lot higher.

Do you want to work in an environment where your target browser is IE6 though (not even joking).

It's still a tricky choice though. By going with Flash you're tying yourself into a dying technology which may not be such a hot choice if you're building a business [1]

I'd still try to go with js/html and shim away as best I could for older IEs.

[1]http://swombat.com/2011/12/7/picking-technologies

Not yet mobile is the last crowd we're supporting. Our application is people that are going to die. You get me?

I work for a company whose target audience tends to be men over 65 years old... And we've seen mobile devices (specifically tablets) grow to nearly 17% of our traffic in the past two years.. I'd say mobile is critical, even more for seniors.

is for people*.

and yes, I'm putting it bluntly ;)

"people that are going to die" so it's aimed at.. everyone then? ;)