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Re:Ozempic-style drugs now in trials for heart failure, addi... by nly on Friday November 06, 2026 @08:12PM (#50400647)
I started wegovy 3 weeks ago (1.5mg oral dose) and so far have felt absolutely nothing, good or bad.

I'm assuming this is normal and something will happen when I up the dose.

Re:Ozempic-style drugs now in trials for heart failure, addi... by seanmcdirmid on Friday November 06, 2026 @11:23PM (#50401592)
Ya, you are still ramping and the smaller doses are to see if there will be problems before you hit 30mg. You should notice something when you hit 10mg though.
Re:Ozempic-style drugs now in trials for heart failure, addi... by gruturo on Saturday November 07, 2026 @06:18AM (#50403546)
30mg is an extremely high dosage, far beyond the maximum Semaglutide (Wegovy) trials (which initially topped out at 2.4 and years later validated a new max of 7.2) and likely to land you in a hospital.

Even 10mg is very, very high, beyond the trials maximums (though preliminary small escalation trials tested that, even reaching 16mg, I guess the participants really didn’t enjoy that) and would have serious side effects if not result in a hospital visit as well.

Please be a lot more careful dispensing advice on a public forum on matters where people could get hurt.

Re:Ozempic-style drugs now in trials for heart failure, addi... by iand on Saturday November 07, 2026 @07:10AM (#50403852)
Oral Wegovy is dispensed in higher doses than injection presumably because uptake via the gut is lower.
Re:Ozempic-style drugs now in trials for heart failure, addi... by JKCalhoun on Saturday November 07, 2026 @09:47AM (#50405007)
Yeah, came here to say you can't compare dosages across drugs—they are in some cases an order of magnitude different.
Re:Ozempic-style drugs now in trials for heart failure, addi... by seanmcdirmid on Saturday November 07, 2026 @03:40PM (#50407834)
I misremembered the dosage, it’s 25 mg, not 30 mg. It’s pretty standard for oral, since absorption is different from injection.