Ozempic-style drugs now in trials for heart failure, addiction and even aging

Re:Ozempic-style drugs now in trials for heart failure, addi... by gruturo on Saturday November 07, 2026 @06:18AM (#50403546)

30mg is an extremely high dosage, far beyond the maximum Semaglutide (Wegovy) trials (which initially topped out at 2.4 and years later validated a new max of 7.2) and likely to land you in a hospital.

Even 10mg is very, very high, beyond the trials maximums (though preliminary small escalation trials tested that, even reaching 16mg, I guess the participants really didn’t enjoy that) and would have serious side effects if not result in a hospital visit as well.

Please be a lot more careful dispensing advice on a public forum on matters where people could get hurt.

[ Parent | on HN ]

Re:Ozempic-style drugs now in trials for heart failure, addi... by iand on Saturday November 07, 2026 @07:10AM (#50403852)

Oral Wegovy is dispensed in higher doses than injection presumably because uptake via the gut is lower.

[ Parent | on HN ]

Re:Ozempic-style drugs now in trials for heart failure, addi... by JKCalhoun on Saturday November 07, 2026 @09:47AM (#50405007)

Yeah, came here to say you can't compare dosages across drugs—they are in some cases an order of magnitude different.

[ Parent | on HN ]

Re:Ozempic-style drugs now in trials for heart failure, addi... by seanmcdirmid on Saturday November 07, 2026 @03:40PM (#50407834)

I misremembered the dosage, it’s 25 mg, not 30 mg. It’s pretty standard for oral, since absorption is different from injection.

[ Parent | on HN ]