And which is better explained as two eugenics programs at clashing into each other, both working on dominating the general populace (Bene Gesserit arguably on larger scale than Komos' single-system thing), and Bene Gesserit using their long-worked socio-religious manipulation for revenge that gets out of hand
the immediate cause of the Jihad is the abortion of the healthy fetus of a Bene Gesserit, Jehanne Butler, by an AI."