The U.S. (and Australia, which was a penal colony) likely has a higher than average (at least for Europe) incidence of what I will call "maverick" traits -- gene based traits that make people less able to go along to get along, for some reason. They aren't necessarily bad traits, they just aren't very conducive to "domestication". The tend to be some of the same traits necessary for activities like exploration and other risky behaviors -- including founding a start up. One of the things YC asks about on its application is rule breaking behaviors. Folks who are too compliant are not well suited for doing groundbreaking work. So I don't personally think that breeding these traits out is necesarily a good thing.

The reason America has higher rates is because a lot of our ancestors left Europe (or other countries) when they just could not fit in. Many left to seek the right to worship as they saw fit -- in other words to think and believe as they wished. So it looks to me like Europe already tried to get rid of these genes and, instead of extinguishing them, mostly exported them, thereby concentrating them in a couple of countries. People with these genes tend to not "go quietly into the night". They tend to go kicking and screaming. So I do not think criminalizing people for having such traits is a good policy. It is better to find ways to help them live constructively with certain traits and to carefully distinguish between traits, which are value neutral, and outcomes or behaviors, which are not value neutral.

I usually do not say this publically, but if Joan of Arc were alive today, she would likely be in a psych ward having her meds adjusted, trying to make the voices stop, instead of playing midwife to the bloody birth of modern Fance. I have also read that Alexander the Great was likely bipolar. Again: I am not so sure that our desire to rid ourselves of people who aren't "normal"/adequately compliant or "cure" them of their differences is such a good thing. I think there are better ways to deal with peope like that than simply trying to break them. I think the goal of breaking them is likely a loss for both the individual being broken and for society. Take that too far and we lose important human traits, like adaptability.

I have a genetic disorder. It is more common in populations which historically were subjected to high death rates from a particular infectious disease (though I don't recall which disease). In other words, carrying at least one gene was likely protective against dying from this infection. Thus this deadly genetic disorder became more common in cases where it helped you survive in the face of worse things. The same is true of Sickle Cell disease, which is protective against malaria. Viewing genetic variations of that sort solely as defects and not as adaptations misses the big picture. If they weren't adaptive in some situations, they wouldn't be selected for by evolutionary pressure.