A bit Lisp-y but with a stronger focus on what in Lisp would be macros.
When first published, REBOL was way ahead of its time, having explicit support for a variety of well-designed DSLs before the term DSL even existed (or at least, was widely known). The downsides of REBOL always were its closed source commercial model and the lack of a strong community as a (probable) result therefore, plus the fact that by default, the UIs made by the built-in UI library look absolutely horrible, which isn't a big problem really but helps scare newcomers away.
That one first downside seems to have been taken away now.
A nice REBOL showcase is, IMHO, it's oneliner page:
http://www.rebol.com/oneliners.html
Plus the (excellent) associated commentary on some mailing list:
http://www.xent.com/pipermail/fork/Week-of-Mon-20091109/0545...
Just a scripting language like Python but with some more stuff included, mainly a cross-platform feature-rich GUI framework? And a very own syntax...
Or more like an embedded programmable VM like Smalltalk?
Also, http://www.red-lang.org was mentioned here (and I also haven't heard about it before). How does that compare?