New HIV vaccine shows unprecedented success in preclinical study

Re:New HIV vaccine shows unprecedented success in preclinica... by simonask on Tuesday July 28, 2026 @10:31AM (#49084502)

Ad-hoc use of PrEP just requires that you take a double dose 1 hour prior to potential exposure, and follow up with another double dose 24 hours later, at least with the versions commonly prescribed to sexually active groups in my area.

I agree that a vaccine is another game-changer, but it’s extremely important that we don’t spread misinformation about the efficacy and convenience of PrEP. In developed societies, it has already all but eliminated new transmissions among groups that were previously most at risk.

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Re:New HIV vaccine shows unprecedented success in preclinica... by jcul on Tuesday July 28, 2026 @11:46AM (#49085653)

Does this double dose completely prevent infection?

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Re:New HIV vaccine shows unprecedented success in preclinica... by matthewmacleod on Tuesday July 28, 2026 @12:01PM (#49085907)

The evidence I’m aware of suggests that this method (on-demand or event-based PrEP) is broadly as effective as daily PrEP (though it’s not suitable for vaginal sex). I believe adherence rates are generally lower though, as people can find the instructions confusing, and it’s obviously easier to mis-dose than a daily regimen.

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Re:New HIV vaccine shows unprecedented success in preclinica... by cyberax on Wednesday July 29, 2026 @03:48AM (#49094535)

It's called a "loading dose" and it's a common trick in medication dosing.

If your drug has an elimination half-life of 1 day, then it takes about 4 days to reach the steady-state concentration if you take normal doses. With the loading dose, you immediately reach it.

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Re:New HIV vaccine shows unprecedented success in preclinica... by tallanvor on Tuesday July 28, 2026 @01:53PM (#49087528)

At least 2 hours before, not 1, and preferably closer to 24 hours before.

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