Shinjuku isn't the worst - it's big, but every part of it has its own distinct feel, you never get confused about where you are. I actually think Ikebukuro is the worst - there are too many places where you can rotate 180 degrees, or move up or down a floor, and find yourself looking at an exactly identical scene.

anyone who hasn't been lost in Shinjuku-eki has not been to Shinjuku-eki. Or has been, but it was Golden Week and the place was nearly empty.

Every person I know me included got lost there multiple times, yet some users here get offended by this somehow.

If you take the gross area of Shinjuku, including its multiple maze-like levels, it is comparable to the size of city centers of Florence or Bologna.