Take things like even certain physics propositions (e.g. discovering new particles) -- can take billions of dollars building a new reactor and years of experiments to find a result.
Anything medical or psychological also can take this result. If a chemical reduces your iq by 5 points over 10 years, it might not be able to do a study that finds that result on an academic budget.
Then again, perhaps we are simply two different types of people. I don’t believe that a complex system can be expected to stay the same when you introduce a new factor into it, while you prefer to adjust much later when effects appear or when evidence achieves total infallibility up to the academic level. I am risk-averse, you like taking it; I’d rather prevent, you’d rather cure. Stating that the former is “far, far more dangerous” is just begging the question though.