News for hackers. Stuff that matters.

A comment on GLP-1 drugs led to weight loss and reversed depression-like behavior in mice. Parent comment

Re:GLP-1 drugs led to weight loss and reversed depression-li... by JumpCrisscross on Saturday June 27, 2026 @08:02PM (#48703021)
> almost all subjects regained the weight and reversed gains within 2 years

Source? I thought it was 2/3rds of the weight regained, which is still a substantial long-term loss.

[ Parent | on HN ]
Re:GLP-1 drugs led to weight loss and reversed depression-li... by shlant on Sunday June 28, 2026 @03:59AM (#48705330)
supposedly that comes mostly from observational studies whereas RCT's seem to show that at some point full regain will probably happen (although can take 1-2 years). The Observational studies don't seem to control for people stopping GLP-1's but still trying other drugs/weight loss methods which is where the discrepancy from RCT's seems to be.
[ Parent | on HN ]
Re:GLP-1 drugs led to weight loss and reversed depression-li... by JumpCrisscross on Sunday June 28, 2026 @09:21AM (#48707050)
> supposedly that comes mostly from observational studies whereas RCT's seem to show that at some point full regain will probably happen

Do you have one you’d recommend reading?

[ Parent | on HN ]