Possibly with https://github.com/tjfontaine/node-libclang. I'm actually working on a node module that will automatically parse header files using libclang and make native dynamic libraries available with no configuration required on the end of the developer. It will eventually be part of https://github.com/olalonde/better-require if you're interested.

How about pure JS PEG generated parser instead of clang? https://github.com/xdenser/node-ffiCparser though that is not finished yet

An didn't know about this, looks great. Would you be interested in helping me write an add-on for better-require? Anyways, I'll try it out and see how it works out.

The actual code generator I haven't published because it was kind of a pile of crap. I created bindings to libclang as well here but haven't finished rewriting a more generalized code generator from it https://github.com/Benvie/node-clang/blob/master/bindings.js