They already donate a lot of useful money via the Chan Zuckerberg Institute so there’s a good track record at least

Chan Zuckerberg Institute doesn't produce much actual research it's mostly fancy dinners, global travel for congresses and conferences and big opulent parties. They actually got in trouble in the building with the landlord for too many parties, there was a problem drunken individuals peeing in the hallways when they had Justin Bieber and other celebs on site (seriously).

Purely anecdata but I know many people who have had their work funded through CZI. And no, this wasn't drunken parties.

Lol cool anecdote. Guess karma for hating on billionaires is more important than saving lives.

It is a valuable initiative, regardless of Zuckerbergs personas.

An attempt to live forever IMO.

Is that an issue?

Just in that it’s not gonna work.

Why not? No law of physics prevents it and we already have examples of (albeit simpler) organisms that can live forever. Worst case scenario, we grow a clone of your body, transplant your brain into it, then somehow repair the spinal cord and slowly replace your brain tissue piece-by-piece. Might be a difficult engineering challenge but it’s 100% possible.

They will probably do a rugpull like what they with their children school funding.

It's also what they did with meta.org (a trademark grab followed by a rugpull): https://en.wikipedia.org/wiki/Meta_(academic_company)

Alternate theory: part of the reason they stopped funding the school is to allocate their philanthropy to projects like this one.